DTPA (0.1 nmol) was labeled with commercial indium-111 chloride (5 × 10 7 cpm) and used as a tracer (15000 cpm in a total incubation volume of 0.3 mL). Incubation with varying concentrations of stable DTPA-metal or EDTA-metal competitors was performed overnight at 4°C in PBS supplemented with BSA.

Indium-DTPA-tagged liposomes were studied in the present work as carriers of in vivo 212Pb/212Bi generator to be used in targeted alpha therapy. The liposomal uptake of 212Pb, into preformed ...

Like indium-111 (In-111) diethylenetriamine-penta-acetic acid (DTPA), this radiopharmaceutical can be used with a concomitant solid meal labeled with Tc-99m SC for gastric imaging and measurement of small-bowel or colon transit. Its long half -life (physical half -life: 78.3 hours) allows extended imaging of the abdomen up to 96 hours or ...

Indium-111 chloride. Indiclor (Nycomed) Mallinckrodt In-111Cl. Labeling monoclonal antibodies and peptides (OncoScint & Octreoscan) Indium-111 pentetate (DTPA) Indium DTPA In-111. Imaging of cerebrospinal fluid kinetics. Indium-111 oxyquinoline (oxine) Indium-111 oxine. Labeling leukocytes and platelets. Indium-111 Capromab pendetide. ProstaScint

Mallinckrodt In-111Cl. for labeling monoclonal antibodies and peptides (OncoScint & Octreoscan) Indium-111 pentetate (DTPA) Indium DTPA In 111. imaging of CSF kinetics. Indium-111 oxyquinoline (oxine) Indium-111 oxine. for labeling leukocytes and platelets. Indium-111 Capromab pendetide.

INDIUM-111 • Chemical Symbol: 111In • Chemical Form: Indium-111 Diethylenetriamine pentaacetic Acid (DTPA) • Half-life: 2.80 days • Manufacturer: GE Healthcare • Trade name(s): Indium DTPA In 111 • Diagnostic use: For use in radionuclide cisternography, Cerebro spinal fluid imaging 13.

111-Indium-DTPA-IgG (1 llln-IgG) is a new radiophar­ ... radiopharmaceuticals that have been used for this purpose. The need to label patient cells in vitro for 111 In­ …

General information. Diethylenetriamine penta-acetic acid (DTPA) is a chelating agent that has been used in radiolabeled form as a tracer. It has been used in the following combinations: 111 indium-DTPA: to label proteins, such as albumin [ 4] and monoclonal antibodies [ 5 ], for the radiodetection of cancers; 99m technetium-DTPA: for scanning ...

Disposal. The half-life of Indium-111 is 2.8 days, so the radioactive material should be left in a secure, locked area until the radioactivity has decayed to levels no larger than background on the Geiger counter, a device used to detect radiation. After which time, they may be placed in …

An evaluation of 113m indium DTPA chelate in the ... The sequential scintiscanning technique was used to determine gastric emptying rates in adult human subjects after ingestion of a meal of cornflakes and milk to which a gamma-emitting radioactive isotope had been added. Comparison of emptying rates using 113m In DTPA chelate and 51 Cr ...

Radioactivity cleared from the liver and lungs as a single exponential with a half-time of 30 minutes, but there was very rapid increase of radioactivity in the lungs, peaking at 1-2 minutes, following the injection of protamine. Indium-111 DTPA-heparin may be used to study in vivo pharmacokinetics and biodistribution of heparin.

The sequential scintiscanning technique was used to determine gastric emptying rates in adult human subjects after ingestion of a meal of cornflakes and milk to which a gamma-emitting radioactive isotope had been added.Comparison of emptying rates using (113m)In DTPA chelate and (51)Cr sodium chromate showed that significantly slower rates were recorded with chromate, and studies in vitro ...

An evaluation of 113m indium DTPA chelate in the measurement of gastric emptying by scintiscanning. R. C. Heading, ... The sequential scintiscanning technique was used to determine gastric emptying rates in adult human subjects after ingestion of a meal of cornflakes and milk to which a gamma-emitting radioactive isotope had been added.

The corresponding retention times for Indium-111 DTPA (n=3) and for Indium-111 chloride (n=3) were 10.75±.01 minutes and 11.12±.02 minutes respectively. 97.4±3.0% of Indium-111 activity applied to the column was recovered within the first 15 minutes and of this 99.2±1.0% (n=18) was associated with the heparin peak at 7 minutes. In all ...

Indium DTPA In 111. Generic Name. Indium In-111 pentetate. DrugBank Accession Number. DB09425. Background. Indium In-111 pentetate disodium is a radioactive diagnostic indicated for use in radionuclide cisternography. Decay of In-111 by electron capture allows for detection with a gamma camera for visualization of the brain and spinal column. Type.

Indium 111 DTPA scintigraphy is a safe, straightforward way to identify and characterize clinical changes associated with intrathecal drug-delivery systems and to guide appropriate and …

Find patient medical information for Indium IN-111 DTPA intrathecal on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings.

Indium-111 forms complexes in which indium is present in the + 3 oxidation state.Either open-chain DTPA or macrocyclic DOTA chelating agents are generally used in indium-111 nuclear medicine applications (Figure 7).In contrast to indium-DTPA which can be formed at room temperature, heat is required to form indium-DOTA complexes [21].

GE Healthcare (Medi-Physics, Inc.) Indium DTPA In 111 is a diagnostic drug for intrathecal use. It is available as a sterile, pyrogen-free, isotonic, aqueous solution, buffered to pH 7 to 8. At calibration time, each milliliter contains 37 MBq, 1 mCi of Pentetate Indium Disodium In 111 (no-carrier-added), 20 to 50 µ g of pentetic acid, and ...

An indium (111) DTPA flow study is a non-invasive, safe and patient friendly diagnostic method which can be of great help in the evaluation of pump- or catheter-related complications and does not ...

Indium-111-DTPA-octreotide has been successfully used for imaging of somatostatin receptor-positive lesions. However, significant renal uptake of 111In-DTPA-octreotide exists, reducing the ...

Methods: A standard refill technique was used to inject 0.3 mL of indium 111 DTPA into the pump reservoir. Radionuclide images were reviewed at varying time points up to 48 hours after injection. The extent of radionuclide progression from the pump reservoir to the intrathecal space was evaluated. In cases in which a problem with the implant ...

DESCRIPTION. GE Healthcare (Medi-Physics, Inc.) Indium DTPA In 111 is a diagnostic drug for intrathecal use. It is available as a sterile, pyrogen-free, isotonic, aqueous solution, buffered to pH 7 to 8. At calibration time, each milliliter contains 37 MBq, 1 mCi of Pentetate Indium Disodium In 111 (no-carrier-added), 20 to 50 µ g of pentetic ...

Indium-111 Octreoscan uses Somatostatin analog; neuroendocrine tumors (neuroblastoma, pheo, medullary thyroid carcinoma, insulinoma, carcinoid, small cell lung cancer, paraganglioma) Indium-111 DTPA uses

MPI Indium DTPA In 111 DESCRIPTION: MPI Indium DTPA In 111 is a diagnostic drug for intrathecal use. It is available as a sterile, pyrogen-free, isotonic, aqueous solution, buffered to pH 7 to 8. At calibration time, each milliliter contains 37 megabecquerels (1 millicurie) of Pentetate Indium …

Pentetate Calcium is the calcium salt form of diethylene triamine pentaacetate (Ca-DTPA or pentetate calcium) with chelating activity.Upon administration, Ca-DTPA loses the Ca ion to form stable chelates with metal ions because DTPA has a higher affinity for heavy metal ions than for Ca ions. Specifically, this agent is able to bind to and form strong complexes with radioactive plutonium ...

INDIUM DTPA In 111 Pentetate Indium Disodium In 111 R ONLY DESCRIPTION GE Healthcare (Medi-Physics, Inc.) Indium DTPA In 111 is a diagnostic drug for intrathecal use. It is available as a sterile, pyrogen-free, isotonic, aqueous solution, buffered to pH 7 to 8. At calibration

indium In 111 [no carrier added, >1.85 GBq/µg indium (>50 mCi/µg indium)] at calibration time, 50 µg oxyquinoline, 100 µg polysorbate 80, and 6 mg of HEPES (N-2-hydroxyethyl-piperazine-N'-2-ethane sulfonic acid) buffer in 0.75% sodium chloride solution. The drug is intended for single use only and contains no bacteriostatic agent.

Indium-111 diethylenetriaminepentaacetic acid (111 In-DTPA) was analyzed by reversed-phase HPLC.On-line u.v. (220 mm) and radioactivity (NaI) detectors allowed simultaneous detection and quantitation of 111 In-DTPA radiopharmaceutical and free DTPA. The optimum HPLC conditions were derived from systematic study of the effect of various mobile phase parameters on …

Radioactivity cleared from the liver and lungs as a single exponential with a half-time of 30 minutes, but there was very rapid increase of radioactivity in the lungs, peaking at 1-2 minutes, following the injection of protamine. Indium-111 DTPA-heparin may be used to study in vivo pharmacokinetics and biodistribution of heparin.

Other radiotracers, such as 99m Tc-inulin and chelated 169 Yb, were also used previously but now have been replaced by 111 In-DTPA because of the optimal half-life of 111 In (2.8 d), allowing for delayed imaging, reasonable γ-photon energies, and absence of β radiation.

Indium-111 (111In)–labelled pentetreotide specifically binds to somatostatin receptors (specially to subtypes 2 and 5). Other somatostatin analogs (eg, technetium 99m depreotide [99mTc depreotide], DTPA) are used in the imaging of pituitary tumors .

In vitro and in vivo studies of substance P receptor expression in rats with the new analog [indium-111-DTPA-Arg1]substance P. Breeman WA(1), VanHagen MP, Visser-Wisselaar HA, van der Pluijm ME, Koper JW, Setyono-Han B, Bakker WH, Kwekkeboom DJ, …

In-111 DTPA Description. In-111 DTPA is supplied as a sterile, pyrogen-free, isotonic, aqueous solution that is buffered to pH 7 to 8. At calibration time, each milliliter contains 2.5 mCi of Pentetate Indium Disodium In-111 (no carrier-added) and sodium bicarbonate for pH adjustment.